The textbook for the course is

- Klein and Moeschberger (2003) Survival analysis - techniques for censored and truncated data, second edition.

The course will be evaluated (pass/fail) by active participation in solving exercises and presenting solutions of exercises.

Vemmetofte data and Thieles report concerning establishing a "klosterforsikring" (materiale venligst stillet til rådighed af Professor Steffen L. Lauritzen).

Catalogue of exercises (updated 11.09.17).

Cirrhosis data and background on these data.

**1. Sep 5 8.15-12** Slides (updated 07.09.17). We will consider examples of duration data and discuss particular aspects of such data. Read KM Chapter 1. Solve exercises 4, 5 and 7 in catalogue of exercises.

**2. Sep 7 8.15-12** Slides (updated 18.09.17). Estimation of the survival function and the cumulative hazard. Read KM 4.1-4.3. Solve exercises 6, 8, 10 (first part), 11 in exercise catalogue. Code for simulation study.

**3. Sep 12 8.15-12 (selfstudy)** basic concepts: survival function, hazard function, mean residual life time. Read KM 2.1-2.4. Solve exercises 1, 2, 3 and 12 in catalogue of exercises.

Solve exercises 4.1 (a)-(d) and exercise 4.5 (a)-(c) in KM (you're welcome to use R survfit() - check documentation via help(survfit.formula)). Data from KM are available in the R-package KMsurv. NB: I am not sure that all solutions in KM are correct.

**4. Sep 14 8.15-12 (selfstudy)** censoring and likelihoods. Read
KM 3.1-3.5. Solve exercises 3.1, 3.3, 3.7 (a) and 3.8 in KM (skip computation of mean and variance of \hat lambda).

**5. **
**5. Sep 18 8.15-12** Slides (updated 23.09.17). Last part of slides regarding estimation of survival function. Log rank test. Cox's proportional hazards model. Solve exercise 9 and 10 (last part) and 15 in ex-cat. The theoretically inclined may also consider exercise 13.

**6. Sep 25 12.30-16 room 2.115** Groups
present exercises. If time allows we also consider Cox's proportional hazards model.

5.222: exercise 4, 5, 4.1, 4.5.

5.224: 3, 10, 3.1.

5.219a: 3.3, 3.7, 3.8.

5.219b: 11, 12.

**7. Sep 28 room 5.034** Cox's proportional hazards model/model assessment. Solve 16, 17, 18 in exercise catalogue. Also give a detailed account of the profile likelihood approach. Check the expression for Cox's discrete time partial likelihood. Read KM 8.1-8.4.

**8. Sep 29 room 2.115** Miniproject: analysis of cirrhosis data.

**9. Oct 5** Miniproject: analysis of cirrhosis data.

**10. Oct 12** Estimating functions and the Cox partial
likelihood score.

**11. Oct 19** Presentation of miniproject.

**12. Oct 23** Counting processes.

**13. Oct 31** Counting processes and time-varying covariates.

**14. Nov 7** Selfstudy: parametric models and parametric
inference.

**15. Nov 14** Various topics, e.g. correlated survival
data, discrete-time models, competing risks.

**16. Nov 21** Presentation of exercises.

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